UVA1 radiation induces apoptosis (cell death) in the presence of active oxygen molecules, such as singlet oxygen, hydrogen peroxide, or superoxide radicals. This activates programmed (induced) and non-programmed (natural) cell death.
UVA1 is considered effective in treating skin diseases by suppressing components of cell-mediated immune function. UVA1 penetrates deep into the reticular layer of the dermis, acting on fibroblasts, dendritic cells and inflammatory cells, especially T cell lymphocytes, as well as mast cells and granulocytes.
The success of UVA1 in atopic dermatitis is found as a result of UVA-induced apoptosis induced in T-helper cells that infiltrate the skin, which causes the loss of T cells from eczematous skin. The effect of UVA1 in inducing T lymphocyte apoptosis can also help treat skin T cell lymphoma (CTCL).
What are the indications for UVA1?
UVA1 radiation can be used to treat the following skin diseases:
Scleroderma (various forms)
Skin T cell lymphoma
Linden sclerosus extragenital
High-dose UVA1 has also been observed to help:
Hypertrophic scars and keloids
Dishidrotic eczema (pompholyx)
There are three dosage regimens for UVA1.
Low dose UVA1 refers to 10-20 J / cm2 per single dose.
Medium-dose UVA1 refers to 50-60 J / cm2 per single dose.
High dose UVA1 refers to 130 J / cm2 per single dose.
The long-term risk of high-dose UVA1 is uncertain, so no more than 10-15 treatments per cycle and two cycles per year is recommended.
If there is a history of photosensitivity, the patient can undergo phototesting to filter out unusual UVA1 reactivity (eg, polymorph light eruption or chronic actinic dermatitis).
UVA1 treatment is done five times a week, usually for 3-4 weeks. However, there are no strict guidelines for their use, and therefore the dose and amount of irradiation can be adjusted for each individual patient, taking into account differences in skin phototypes and their skin problems.
• Philips UVA1 Bulb 365nm (model:PL-S 9W/10-2P)
• Integrated Power Adjustment
• 110 V (U.S./Canada/Other) or 220 V (UK/Europe/Other) power cord adapter
• 1 x Box
• 1 x UVA Phototherapy Device (without built-in timer)
• 1 x UVA Bulb 365nm (Philips, Model: PL-S 9W/10-2P)
• 1 x Transparent Hair Comb Attachment
• 1 x UV Glasses
• 1 x User Manual
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